反応 #988

反応方程式

172

4-(4-tert-Butyldiphenylsilyloxymethyl-phenyl)butyraldehyde

120

3-Phenyl-1-propylmagnesium bromide

121

1,7-Diphenyl-4-heptanol

→

alcohol

収率 122.9%

1-(4-tert-Butyldiphenylsilyloxymethylphenyl)-7-phenyl-heptan-4-ol

収率 122.9%

溶媒

THF

反応条件

後処理

1. 1
   洗浄Flash chromatography (elution with 10% ethyl acetate in hexane)

実験手順

The alcohol 173 was prepared from 2.12 g (5.0 mmol) of 172 and 9.0 mL (9 mmol) of 120 in 50 mL of THF as described for the synthesis of 121 in Example 1. Flash chromatography (elution with 10% ethyl acetate in hexane) gave 3.3 g of the alcohol 173. 1H NMR consistent with the product.

出典