反応 #987486

反応方程式

2-[4-amino-2-oxo-1-pyrrolidinyl]butanamide

dimethoxytetrahydrofurane

pyridine

→

223

収率 39.4%

4-pyrol-pyrrolidin-2-one

収率 39.4%

溶媒

AcOH

反応条件

後処理

1. 1
   workup.DISSOLUTIONdissolution
2. 2
   温度the reaction is cooled down to room temperature
3. 3
   濃縮concentrated in vacuo
4. 4
   その他the crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v))

実験手順

In a three necked flask, under argon, a suspension of 2-[4-amino-2-oxo-1-pyrrolidinyl]butanamide 393 (6.99 g, 0.037 mol.), dimethoxytetrahydrofurane (5.53 g, 0.041 mol.), pyridine (50.6 ml) and AcOH (36 ml) is warmed to 70° C. and dissolution occurs. After 2 h at this temperature, the reaction is cooled down to room temperature, concentrated in vacuo and the crude product is purified by chromatography on silicagel (CH2Cl2/MeOH: 95/05 (v/v)) to afford 223 as an oil (2.67 g, 30.1%). 5.7. Bromination of 4-pyrrolyl-pyrrolidin-2-one 223

出典