反応 #987054

反応方程式

HCl

N-hexylbenzylamine

(4-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid

EDC

→

Methyl 2-[(4-{2-[benzyl(hexyl)amino]-2-oxoethyl}phenoxy)methyl]benzoate

溶媒

water

DCM

反応条件

後処理

1. 1
   その他The two phases were separated
2. 2
   ろ過Filter Tube
3. 3
   その他The obtained organic solution was evaporated in vacuum
4. 4
   workup.WAITthe oil product (71 mg) was left

実験手順

(4-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid (50 mg, 0.166 mmol) was dissolved in DCM (2 ml), N-hexylbenzylamine (38.2 mg, 0.2 mmol) was added, then EDC (38.3 mg, 0.2 mmol) was added and then DMAP (24.4 mg, 0.2 mmol) was added. The mixture was stirred at room temperature overnight. 1% HCl (1 ml) and water (1 ml) were added into the mixture. The two phases were separated by using a Whatman Filter Tube. The obtained organic solution was evaporated in vacuum and the oil product (71 mg) was left. It was then used directly in next step.

出典