反応 #986243

反応方程式

[4-(Methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester

LiAlH4

→

(4-formyl-cyclohexyl)-carbamic acid tert-butyl ester

収率 105.8%

溶媒

ether

反応条件

後処理

1. 1
   その他The reaction mixture was quenched by careful addition of water
2. 2
   抽出extracted with CHCl3
3. 3
   その他The mixture was dried
4. 4
   濃縮concentrated under reduced pressure

実験手順

[4-(Methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (7.50 g, 26.2 mmol) in dry ether (150 ml) was reduced with an excess LiAlH4. The reaction mixture was quenched by careful addition of water and extracted with CHCl3. The mixture was dried and concentrated under reduced pressure to give (4-formyl-cyclohexyl)-carbamic acid tert-butyl ester (6.30 g, 93%).

出典