反応 #9856

反応方程式

4-chloro-2-methylthiopyrimidine

potassium fluoride

→

4-fluoro-2-methylthiopyrimidine

収率 63.1%

溶媒

tetraglyme

反応条件

後処理

1. 1
   温度The mixture was then cooled
2. 2
   workup.DISTILLATIONdistilled under reduced pressure

実験手順

To a solution of 35.7 g (0.22 mol) of 4-chloro-2-methylthiopyrimidine (Aldrich Chemical Co., Milwaukee, Wis., USA) in 135 mL of tetraglyme was added 18-crown-6 (1.33 g) and potassium fluoride (Anhydrous, Aldrich Chemical Co., Milwaukee, Wis., USA, 80 g). The mixture was heated at 150° C.with stirring for 16 hours. The mixture was then cooled and distilled under reduced pressure to give 20 g (62%) of 4-fluoro-2-methylthiopyrimidine as a liquid.

出典