反応 #985276

反応方程式

p-Bromo-benzaldehyde

ammonium acetate

malonic acid

→

p-bromo-β-phenylalanine

収率 63.0%

溶媒

ethanol water

反応条件

後処理

1. 1
   温度heated
2. 2
   ろ過filtered
3. 3
   温度under heating
4. 4
   その他dried under reduced pressure

実験手順

p-Bromo-benzaldehyde (10.0 g, 54 mmol) was mixed with 100 ml of ethanol/water (95/5), 8.3 g of ammonium acetate (108 mmol), and 11.2 g of malonic acid (108 mmol), heated under reflux at 80° C. with stirring for 17 hours, filtered under heating and dried under reduced pressure to give 8.3 g of p-bromo-β-phenylalanine crystals at a yield of 62.8%.

出典