反応 #985264

反応方程式

dimethyl-5-nitroisophthalate

ethanolamine

→

N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide

収率 67.3%

溶媒

methanol

反応条件

後処理

1. 1
   温度was refluxed for 48 hours
2. 2
   その他The solvent was removed by evaporation under reduced pressure
3. 3
   その他The crude product was purified by crystallization from EtOAC

実験手順

A solution containing dimethyl-5-nitroisophthalate (23.9 g, 100 mmol) and ethanolamine (13.4 g, 220 mmol) in methanol (300 mL) was refluxed for 48 hours. The solvent was removed by evaporation under reduced pressure. The crude product was purified by crystallization from EtOAC:MeOH 1 ml v/v) to afford 20.0 g of pure N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide as white crystals. m.p.=151.3-151.4° C., uncorrected

出典