反応 #985262

反応方程式

2-(4-nitrophenyl)benzothiazole

tin (II) chloride dihydrate

→

2-(4-Aminophenyl)benzothiazole

溶媒

ethanol

反応条件

後処理

1. 1
   温度was refluxed under N2 for 4 hrs
2. 2
   その他After removing ethanol
3. 3
   その他by vacuum evaporation
4. 4
   workup.DISSOLUTIONThe residue was dissolved into ethyl acetate (20 ml)
5. 5
   洗浄washed with NaOH solution (1 N, 3×20 ml) and water (3×20 ml)
6. 6
   その他dried
7. 7
   その他evaporated to dryness to givelo2 mg (97%) of the product

実験手順

A mixture of 2-(4-nitrophenyl)benzothiazole (105 mg, 0.40 mmol) and tin (II) chloride dihydrate (205 mg, 0.91 mmol) in ethanol (20 mL) was refluxed under N2 for 4 hrs. After removing ethanol by vacuum evaporation. The residue was dissolved into ethyl acetate (20 ml), and washed with NaOH solution (1 N, 3×20 ml) and water (3×20 ml), dried and evaporated to dryness to givelo2 mg (97%) of the product

出典