反応 #985261

反応方程式

4-nitrobenzoyl chloride

2-aminothiophenol

→

product

収率 73.2%

2-(4-Nitrophenyl)benzothiazole

収率 73.2%

溶媒

benzene

反応条件

後処理

1. 1
   その他The reaction was quenched with water (20 mL)
2. 2
   その他The aqueous layer was separated
3. 3
   抽出extracted with ethyl acetate (3×10 ml)
4. 4
   その他The combined organic layers were dried
5. 5
   その他evaporated
6. 6
   その他The crude product was purified
7. 7
   その他with flush column, (hexane:ethyl acetate=85:15)

実験手順

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

出典