反応 #985260

反応方程式

6-methoxy-2-(4-nitropheyl)benzothiazbles

6-Methoxy-2-(4-nitrophenyl)benzothiazole

tin (II) chloride dihydrate

→

product 6

収率 97.0%

6-Methoxy-2-(4-aminophenyl)benzothiazole

収率 97.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他Ethanol was evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate (10 mL)
3. 3
   洗浄washed with 1 N sodium hydroxide (2 mL) and water (5 mL)
4. 4
   乾燥dried over MgSO4
5. 5
   その他Evaporation of the solvent

実験手順

A mixture of the 6-methoxy-2-(4-nitropheyl)benzothiazbles 5 (22 mg, 0.077 mmol) and tin (II) chloride dihydrate (132 mg, 0.45 mmol) in boiling ethanol was stirred under nitrogen for 4 hrs. Ethanol was evaporated and the residue was dissolved in ethyl acetate (10 mL), washed with 1 N sodium hydroxide (2 mL) and water (5 mL), and dried over MgSO4. Evaporation of the solvent gave 19 mg (97%) of the product 6 as yellow solid.

出典