反応 #985254

反応方程式

chlorotrimethylsilane

acetylacetone

1-methylimidazole

→

4-trimethylsilyloxypent-3-en-2-one

収率 81.4%

反応条件

後処理

1. 1
   その他to form a liquid biphasic mixture
2. 2
   その他Removal of the upper phase

実験手順

5.97 g (55.0 mmol) of chlorotrimethylsilane were added dropwise while stirring at 0° C. to a solution of 5.00 g (49.9 mmol) of acetylacetone and 4.50 g (55.0 mmol) of 1-methylimidazole. The reaction mixture was stirred at 0° C. for a further 1 h and at 80° C. for 5 min to form a liquid biphasic mixture. Removal of the upper phase gave 7.00 g (theory: 8.60 g) of 4-trimethylsilyloxypent-3-en-2-one as a bright yellow, cloudy oil having a purity of 84% (GC).

出典