反応 #985252

反応方程式

chlorotrimethylsilane

neopentyl alcohol

1-methylimidazole

→

2,2-dimethyl-1-trimethylsilyloxypropane

収率 85.8%

反応条件

後処理

1. 1
   その他Removal of the upper phase

実験手順

6.50 g (56.7 mmol) of chlorotrimethylsilane were added dropwise while stirring at 0° C. to a solution of 5.00 g (56.7 mmol) of neopentyl alcohol (2,2-dimethyl-1-propanol) and 11.6 g (142 mmol) of 1-methylimidazole. The reaction mixture was stirred at 0° C. for a further 2 h and at 20° C. for 2.5 h. Removal of the upper phase gave 7.80 g (theory: 9.09 g) of 2,2-dimethyl-1-trimethylsilyloxypropane as a colorless oil having a purity of 96% (GC).

出典