反応 #985250

反応方程式

chlorotrimethylsilane

1-butanol

1-methylimidazole

→

1-trimethylsilyloxybutane

収率 89.4%

反応条件

後処理

1. 1
   その他to form a liquid biphasic mixture
2. 2
   その他Removal of the upper phase

実験手順

4.40 g (40.5 mmol) of chlorotrimethylsilane were added dropwise while stirring at 0° C. to a solution of 3.00 g (40.5 mmol) of 1-butanol and 11.1 g (135 mmol) of 1-methylimidazole. The reaction mixture was stirred at from 0 to 5° C. for a further 15 min and at 20° C. for 15 min to form a liquid biphasic mixture. Removal of the upper phase gave 5.30 g (theory: 5.93 g) of 1-trimethylsilyloxybutane as a colorless oil having a purity of 90% (GC).

出典