反応 #985249

反応方程式

acetyl chloride

neopentyl alcohol

1-methylimidazole

→

neopentyl acetate

収率 86.0%

反応条件

後処理

1. 1
   その他The suspension which had formed in the meantime
2. 2
   その他Removal of the upper phase

実験手順

6.47 g (82.5 mmol) of acetyl chloride were added dropwise with stirring at 20° C. to a solution of 6.61 g (75.0 mmol) of neopentyl alcohol (2,2-dimethyl-1-propanol) and 6.76 g (82.5 mmol) of 1-methylimidazole. The reaction mixture was stirred for a further 30 min and then heated to 75° C. The suspension which had formed in the meantime was converted to a liquid biphasic mixture. Removal of the upper phase gave 8.40 g (theory: 9.76 g) of neopentyl acetate as a colorless oil having a purity of 98% (GC).

出典