反応 #985244

反応方程式

sodium azide

p-toluenesulfonyl chloride

→

title compound

収率 80.3%

p-toluenesulfonylazide

収率 80.3%

溶媒

ethanol

H2O

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise at 10-25° C.
2. 2
   その他followed by reaction at room temperature for 2.5 hours
3. 3
   濃縮The reaction solution was concentrated at room temperature under reduced pressure
4. 4
   洗浄The resulting oily residue was washed with H2O several times
5. 5
   乾燥dried over anhydrous MgSO4
6. 6
   その他After removing the drying agent
7. 7
   ろ過by filtration

実験手順

After dissolving sodium azide (22.5 g, 0.35 mole) in a small amount of H2O, the resulting solution was diluted with a 90% ethanol aqueous solution (130 ml). To this, an ethanol solution dissolving p-toluenesulfonyl chloride (60 g, 0.32 mole) was added dropwise at 10-25° C., followed by reaction at room temperature for 2.5 hours. The reaction solution was concentrated at room temperature under reduced pressure. The resulting oily residue was washed with H2O several times and dried over anhydrous MgSO4. After removing the drying agent by filtration, there was obtained 50.7 g of the title compound as a colorless oil.

出典