反応 #9820

反応方程式

4-Nitro-phthalic anhydride

2-amino-2-methylpropanol

water

→

2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol

溶媒

CH2Cl2

反応条件

後処理

1. 1
   温度After cooling
2. 2
   その他the organic phase separated
3. 3
   濃縮concentrated
4. 4
   その他purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3)

実験手順

20 g of 4-Nitro-phthalic anhydride and 8.94 g of 2-amino-2-methylpropanol were heated to 170° C. for 30 min. After cooling, water and CH2Cl2 were added, and the organic phase separated, concentrated and purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3).

出典