反応 #978102

反応方程式

4-iodobenzoic acid

pentafluorophenol

diisopropylcarbodiimide

glucosamine hydrochloride

NEt3

→

4-iodobenzoyl glucosamine

溶媒

DMF

DMF H2O

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction was stirred for 16 hours
2. 2
   その他crystallized from hot water

実験手順

To a solution of 4-iodobenzoic acid (1 mmol) in DMF (2 mL) was added pentafluorophenol (2 mmol) and diisopropylcarbodiimide (1.2 mmol). The solution was stirred at room temperature for 6 hours and then added to a solution of glucosamine hydrochloride (1 mmol) and NEt3 (2 mmol) in DMF/H2O (1 mL, 1:10 v/v). The reaction was stirred for 16 hours and then crystallized from hot water to yield 4-iodobenzoyl glucosamine, compound TP010. The structure of TP010 is shown below (R is I).

出典