反応 #975233

反応方程式

4-(chloromethyl)benzoic acid

ethyl 4-aminobutyrate

ethyl 4-aminobutyrate hydrochloride

→

compound 13g

Ethyl 4-(4-(chloromethyl)benzamido)butanoate

反応条件

後処理

1. 1
   その他Ethyl 4-(4-(chloromethyl)benzamido)butanoate 13g was prepared

実験手順

Ethyl 4-(4-(chloromethyl)benzamido)butanoate 13g was prepared by coupling 4-(chloromethyl)benzoic acid 24 with ethyl 4-aminobutyrate 26 according to the procedure described for the compound 13e in Example 21 (Scheme 8). The compound 13g was isolated as colorless oil in 89% yield (2.52 g). 1H NMR (400 MHz, CDCl3): δ 1.24 (3H, t, J=6.8 Hz); 1.96 (2H, quint, J=7.2 Hz); 2.44 (2H, t, J=7.2 Hz); 3.52 (2H, t, J=7.2 Hz); 4.10 (2H, q, J=6.8 Hz); 4.60 (2H, s); 6.62 (1H, broad s); 7.44 (1H, s); 7.46 (1H, s); 7.76 (1H, s); 7.78 (1H, s). MS (ESI): m/z=284.00 (M+H+).

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