反応 #975040

反応方程式

bromine

bromine

3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester

Intermediate B

3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester

sodium carbonate

sodium carbonate

→

title compound

3-Amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester

溶媒

acetic acid

acetic acid

acetic acid

water

反応条件

後処理

1. 1
   workup.WAITthe reaction mixture was left
2. 2
   ろ過the resulting yellow precipitate was filtered under vacuum

実験手順

To a solution of 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate B) (30 mg, 0.13 mmol) in acetic acid (5 ml), sodium carbonate (15 mg, 0.14 mmol) was added. To this mixture, half the contents of a solution of bromine (7 μL, 0.13 mmol) in acetic acid (5 ml) were added, followed by the addition of sodium carbonate ((15 mg, 0.14 mmol). The remaining solution of bromine in acetic acid was added and the reaction mixture was left to stir at RT for 2 hours. The mixture was diluted with water and the resulting yellow precipitate was filtered under vacuum to afford the title compound.

出典