反応 #975030

反応方程式

3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid

Intermediate C

3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid

2-(1H-imidazol-2-yl)propan-1-amine

Racemic histamine

Histamine

→

title compound

N-(2-(1H-imidazol-2-yl)propyl)-3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxamide

反応条件

後処理

1. 1
   その他prepared

実験手順

The title compound was prepared from 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate C) and 2-(1H-imidazol-2-yl)propan-1-amine (prepared according to the procedure of Steffens, Robert; Schunack, Walter. Histamine analogs, XXVI. Racemic histamine H1-agonists. Archiv der Pharmazie (Weinheim, Germany) (1984), 317(9), 771-6; 1H NMR (400 MHz, DMSO-d6) δ 11.8 (1H, s), 9.0 (1H, t), 8.1 (2H, s), 7.0 (1H, s), 6.8 (1H, s), 3.55 (2H, m), 3.15 (1H, m), 1.2 (3H, d). LC-MS [M+H]+ 393.0/395.1

出典