反応 #9745

反応方程式

Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

intermediate 44

Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

triphenylphosphine

→

title compound

({3-(methoxycarbonyl)-5-[4-(trifluoromethyl)phenyl]-2-furyl}methyl)(triphenyl)phosphonium bromide

溶媒

toluene

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux for 1 hour
3. 3
   温度to cool
4. 4
   ろ過the white precipitate was collected by filtration
5. 5
   洗浄washed with fresh toluene

実験手順

Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate (intermediate 44, 0.20 g) was dissolved in toluene (3 ml) treated with triphenylphosphine (0.159 g) and heated to reflux for 1 hour. The reaction was allowed to cool and the white precipitate was collected by filtration, washed with fresh toluene to give the title compound as a white powder.

出典