反応 #9733

反応方程式

4′-(trifluoromethyl)acetophenone

N-(1,1-dimethoxyethyl)-N,N-dimethylamine

→

title compound

3-(dimethylamino)-1-[4-(trifluoromethyl)phenyl]but-2-en-1-one

溶媒

diethyl ether

反応条件

後処理

1. 1
   温度The reaction mixture was cooled
2. 2
   濃縮concentrated
3. 3
   その他giving an orange solid

実験手順

A mixture of 4′-(trifluoromethyl)acetophenone (9.8 g) and N-(1,1-dimethoxyethyl)-N,N-dimethylamine (8.2 g) was heated at 112° C. overnight, under nitrogen. The reaction mixture was cooled and concentrated giving an orange solid. Trituration with diethyl ether gave the title compound as a yellow solid

出典