反応 #972832

反応方程式

2-amino-5-bromo-N,3-dimethylbenzamide

1-methylnaphthalene

sodium cyanide

1-methyl-1H-imidazole

→

title compound

2-amino-5-cyano-N,3-dimethylbenzamide

溶媒

Water

反応条件

後処理

1. 1
   その他A 100-mL, three-necked flask equipped with a mechanical stirrer
2. 2
   温度while maintaining a flow of nitrogen through a gas inlet line
3. 3
   温度The mixture was heated to between 160 and 165° C. for 6 h
4. 4
   その他transferred to a 200-mL flask
5. 5
   温度to cool overnight
6. 6
   workup.STIRRINGwhile stirring
7. 7
   workup.STIRRINGAfter stirring for an additional 2 h
8. 8
   ろ過the reaction mixture was filtered
9. 9
   洗浄the collected solid was washed with water (3×10 mL) and xylenes (10 mL)
10. 10
    その他dried to a constant weight in a vacuum-oven at 80° C.

実験手順

A 100-mL, three-necked flask equipped with a mechanical stirrer, thermometer and condenser was charged with 2-amino-5-bromo-N,3-dimethylbenzamide (prepared by the method of Reference Example 1) (5.0 g, 0.02 mol, 99.1% purity) and 1-methylnaphthalene (20 g) while maintaining a flow of nitrogen through a gas inlet line connected to the condenser. The reaction mixture was stirred at room temperature and sodium cyanide (ground to a powder just prior to use) (1.25 g, 0.024 mol, assuming 95% purity), copper(I) iodide (0.57 g, 0.003 mol, 98% purity) and 1-methyl-1H-imidazole (1.40 g, 0.017 mol, 99%) were added. The mixture was heated to between 160 and 165° C. for 6 h and then transferred to a 200-mL flask and allowed to cool overnight. Water (20 mL) was added dropwise to the reaction mixture over 5 minutes while stirring. After stirring for an additional 2 h, the reaction mixture was filtered and the collected solid was washed with water (3×10 mL) and xylenes (10 mL) and dried to a constant weight in a vacuum-oven at 80° C. to give the title compound as a light brown solid (3.85 g).

出典