反応 #972707

反応方程式

Intermediate 7

{2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl}benzene

potassium phthalimide

→

title compound

収率 49.0%

2-[6-(2,2-Difluoro-2-phenylethoxy)hexyl]-1H-isoindole-1,3(2H)-dione

収率 49.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   その他Purification by column chromatography with silica gel
3. 3
   洗浄eluting with methylene chloride

実験手順

To a solution of Intermediate 7 (10.9 g, 34 mmol) in dimethylformamide (23 mL) was added potassium phthalimide (7.56 g, 40.8 mmol) and a catalytic amount of (n-hexadecyl)tri-n-butylphosphonium bromide. The mixture was heated at 70° C. for 3 hours. The solvent was removed under reduced pressure. Purification by column chromatography with silica gel, eluting with methylene chloride yielded the title compound (6.41 g, 49%) as oil.

出典