反応 #972274

反応方程式

4,4′-dihydroxystilbene

→

4-[4-Hydroxy-phenethyl]-phenol

収率 97.1%

溶媒

MeOH

EtOAc

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他Chromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1)

実験手順

A solution of 4,4′-dihydroxystilbene (250 mg, 1.178 mmol) in MeOH (10 mL) and EtOAc (2 mL) containing 5% Pd—C (120 mg) was stirred under an atmosphere of hydrogen for 2 h. The catalyst was removed by filtration and the filtrate was concentrated. Chromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1) provided 245 mg of 4-[4-Hydroxy-phenethyl]-phenol (97%) as a white solid. MS (ES) m/z: 213.05 (M−1).

出典