反応 #969893

反応方程式

1-(adamantan-2-yl)-4-(2,5-dihydrobenzo[b]oxepin-9-yl)-3,3-dimethylazetidin-2-one

→

1-(adamantan-2-yl)-3,3-dimethyl-4-(benzo[b]oxepan-9-yl)azetidin-2-one

収率 76.2%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The reaction solution was filtered
2. 2
   濃縮concentrated in vacuo

実験手順

A solution of 1-(adamantan-2-yl)-4-(2,5-dihydrobenzo[b]oxepin-9-yl)-3,3-dimethylazetidin-2-one (21.1 mg, 0.0560 mmol) in methanol (2 mL) was added with palladium carbon ethylenediamine complex (catalyst amount), and the resultant was stirred at room temperature for 6 hours under a hydrogen atmosphere. The reaction solution was filtered using celite, concentrated in vacuo, and 1-(adamantan-2-yl)-3,3-dimethyl-4-(benzo[b]oxepan-9-yl)azetidin-2-one (16.2 mg, 76.2%) was obtained as a colorless oil.

出典