反応 #969877

反応方程式

6-aminoquinoline

1-hydroxibenzotriazol

Z-Val-Pro-OH

N,N′-diisopropylcarbodiimide

→

Z-Val-Pro 6-aminoquinoline

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他was continued until the complete disappearance of the starting material (overnight)
2. 2
   その他Then, the solvent was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
4. 4
   洗浄washed with citric acid (10%), NaHCO3 (10%) and brine
5. 5
   乾燥The organic layer was dried (Na2SO4)
6. 6
   その他evaporated
7. 7
   その他leaving a residue that
8. 8
   その他was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4)
9. 9
   その他to yield H (20
10. 10
    その他yield

実験手順

A solution of Z-Val-Pro-OH (217.4 mg, 0.62 mmol) in dichloromethane (1.5 mL), was successively treated at room temperature. with 1-hydroxibenzotriazol (84.3 mg, 0.62 mmol), N,N′-diisopropylcarbodiimide (97.2 μL, 0.62 mmol) and 6-aminoquinoline (75 mg, 0.52 mmol). The stirring was continued until the complete disappearance of the starting material (overnight). Then, the solvent was evaporated, the residue was dissolved in ethyl acetate and washed with citric acid (10%), NaHCO3 (10%) and brine. The organic layer was dried (Na2SO4) and evaporated leaving a residue that was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4) to yield H (20 yield

出典