反応 #969874

反応方程式

( D )

Z-Val-Pro-Val-Pro Ara-C

→

H-Val-Pro-Val-Pro Ara-C

収率 90.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   その他the filtrate was evaporated to dryness, under reduced pressure
3. 3
   その他to give D (90% yield)

実験手順

A solution of the corresponding Ara-C-tetrapeptide-Z-protected (D) (24.7 mg, 0.03 mmol) in methanol containing Pd/C (10% wt/wt) (11.5 mg) was hydrogenated at 25 psi at room temperature for 2 h. The reaction mixture was filtered, and the filtrate was evaporated to dryness, under reduced pressure, to give D (90% yield).

出典