反応 #966

反応方程式

3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine

→

title compound

収率 67.1%

3-(N-tert-butyloxycarbonylaminomethyl) azetidine

収率 67.1%

溶媒

MeOH

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   その他the solvent evaporated
3. 3
   その他The crude product was purified by flash chromatography

実験手順

3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.

出典