反応 #96256

反応方程式

maleic acid

triethylamine

2-guanidino-4-[(2-aminoethyl)thiomethyl]thiazole hydrochloride

Methyl isothiocyanate

→

2-guanidino-4-[2-(3-methylthioureido)ethylthiomethyl]thiazole hydrogen maleate

溶媒

acetone

acetone

methanol

反応条件

後処理

1. 1
   その他to give a pale yellow solution
2. 2
   その他Evaporation of the solvent
3. 3
   その他gave a gum which
4. 4
   ろ過The precipitate was filtered off
5. 5
   その他recrystallized from ethanol

実験手順

A suspension of 2-guanidino-4-[(2-aminoethyl)thiomethyl]thiazole hydrochloride (1.52 g.) in methanol (30 ml.) was treated with triethylamine (1.01 g.) to give a pale yellow solution. Methyl isothiocyanate (0.365 g.) was added and the solution stirred for 16 hours at room temperature. Evaporation of the solvent gave a gum which was dissolved in acetone (20 ml.) and treated with maleic acid (1 g.) in acetone (20 ml.). The precipitate was filtered off and recrystallized from ethanol to give 2-guanidino-4-[2-(3-methylthioureido)ethylthiomethyl]thiazole hydrogen maleate as a pale brown solid (0.420 g.). Found: C, 37.4; H, 4.7; N, 19.8; S, 22.7. C13H20N6S3O4 requires C, 37.14; H, 4.76; N, 20.00; S, 22.85%.

出典