反応 #962

反応方程式

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

収率 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

収率 92.0%

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   抽出the mixture was extracted three times with ethyl acetate
2. 2
   洗浄The combined organic layer was washed with brine
3. 3
   乾燥dried (Na2SO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated

実験手順

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

出典