反応 #96192

反応方程式

4-Aminobutanol

N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea

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title compound

収率 38.6%

N-Cyano-N'-(4-hydroxybutyl)-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine

収率 38.6%

溶媒

ethanol

反応条件

後処理

1. 1
   その他The reaction mixture was evaporated
2. 2
   その他to yield an oil which
3. 3
   その他was chromatographed on a silica gel column
4. 4
   洗浄eluted with chloroform and chloroform/methanol (20:1)

実験手順

4-Aminobutanol (2.7 g) and N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (4.05 g) were refluxed in ethanol (30 ml) for 4 hours. The reaction mixture was evaporated to yield an oil which was chromatographed on a silica gel column and eluted with chloroform and chloroform/methanol (20:1) to give the title compound as a colourless oil (1.8 g).

出典