反応 #961

反応方程式

(3RS)-1-benzyl-3-hydroxymethyl pyrrolidine

thionyl chloride

→

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

溶媒

CHCl3

CHCl3

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water

実験手順

To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.

出典