反応 #959451

反応方程式

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole

1-(2,2-dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole

→

1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-amine

溶媒

ethanol

反応条件

後処理

1. 1
   その他flushed with nitrogen
2. 2
   その他The mixture was sparged under hydrogen (1 atm)
3. 3
   ろ過The mixture was filtered through a pad of Celite
4. 4
   洗浄the residue was washed with MeOH
5. 5
   濃縮The filtrate was concentrated

実験手順

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (2-3) (4.46 g, 19.04 mmol, 1.0 equiv) was dissolved in ethanol (50 ml) and flushed with nitrogen, then charged with 10% Pd/C (2.026 g, 1.904 mmol, 0.1 equiv). The mixture was sparged under hydrogen (1 atm) and stirred at room temperature for 5 hrs. The mixture was filtered through a pad of Celite and the residue was washed with MeOH. The filtrate was concentrated to give the crude 1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-amine (2-4 LRMS m/z (M+H) 205.0 found, 205.3 required.

出典