反応 #959450

反応方程式

2-Fluoro-5-nitroaniline

neopentylamine

sodium nitrite

NaOH

→

1-(2,2-dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole

溶媒

water

acetic acid

DMSO

反応条件

後処理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   その他a precipitation
3. 3
   その他The solid was collected on top
4. 4
   ろ過of filter
5. 5
   洗浄washed twice with water
6. 6
   その他The crude solid was purified with silica gel chromatography (EtOAc/hexanes gradient from 0 to 100%)

実験手順

2-Fluoro-5-nitroaniline (2-1) (10.22 g, 65.5 mmol, 1.0 equiv.) was dissolved in anhydrous DMSO (100 ml), and treated with neopentylamine (2-2) (7.71 ml, 65.5 mmol, 1.0 equiv.). The reaction mixture was heated at 120° C. for 2 days when LCMS showed mostly product with trace of starting material. The reaction mixture was cooled to room temperature and treated with acetic acid (25 ml), followed by addition of 2.0 M aqueous solution of sodium nitrite (121 ml, 79 mmol, 1.2 equiv.). LCMS showed product after the reaction mixture was stirred at ambient temperature for 20 minutes. The mixture was then neutralized to pH=7 with NaOH (1N) and diluted with water which caused a precipitation. The solid was collected on top of filter and washed twice with water. The crude solid was purified with silica gel chromatography (EtOAc/hexanes gradient from 0 to 100%) to yield 1-(2,2-dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (2-3). 1H NMR (CDCl3) δ 9.02 (d, 1H, J=2.0 Hz), 8.40 (dd, 1H, J=9.1, 2.0 Hz), 7.62 (d, 1H, J=9.1 Hz), 4.47 (s, 2H), 1.07 (s, 9H) ppm. LRMS m/z (M+H) 235.1 found, 235.3 required.

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