反応 #9594

反応方程式

N-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]methanesulfonamide

→

N-[2-(3-amino-7-bromoquinolin-4-ylamino)ethyl]methanesulfonamide

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The vessel was evacuated
2. 2
   workup.ADDITIONfilled with hydrogen (45 psi, 3.1×105 Pa)
3. 3
   ろ過The reaction mixture was filtered through CELITE
4. 4
   ろ過filter agent
5. 5
   濃縮concentrated under reduced pressure

実験手順

An 8 L stainless steel Parr vessel was charged with N-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]methanesulfonamide (61 g), 5% Pt/C catalyst (6.0 g) and acetonitrile (3 L). The vessel was evacuated, filled with hydrogen (45 psi, 3.1×105 Pa), and shaken at ambient temperature overnight. The reaction mixture was filtered through CELITE filter agent and concentrated under reduced pressure to provide N-[2-(3-amino-7-bromoquinolin-4-ylamino)ethyl]methanesulfonamide.

出典