反応 #958987

反応方程式

calcium chloride dihydrate

calcium chloride

NaOH

calcium chloride

sodium alendronate trihydrate

sodium tripolyphosphate

Na5P3O10

→

alendronate

tripolyphosphate

溶媒

water

water

反応条件

後処理

1. 1
   ろ過The precipitate was collected by filtration
2. 2
   洗浄washed with water
3. 3
   その他The solid was dried in an oven at 120° C. overnight

実験手順

2.03 g sodium alendronate trihydrate (6.25 mmol) and 6.9 g sodium tripolyphosphate, Na5P3O10 were added to 100 mL water, and the mixture was stirred until all dissolved. 10.34 g calcium chloride dihydrate were dissolved in 200 mL water. The calcium chloride solution was heated to 40° C. and the pH was adjusted to 7.0. The alendronate-tripolyphosphonate solution was added into the calcium chloride solution dropwise, keeping the pH of the resulting solution at 7.0 by adding 1N NaOH. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 120° C. overnight. 8.82 g of calcium complex salt of alendronate with tripolyphosphate was thus obtained.

出典