反応 #9570

反応方程式

5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

→

7-bromoquinolin-4-ol

5-bromoquinolin-4-ol

溶媒

DOWTHERM A

反応条件

後処理

1. 1
   温度heat transfer fluid for one hour
2. 2
   その他A precipitate formed
3. 3
   温度upon cooling
4. 4
   その他was isolated by filtration
5. 5
   洗浄washed with diethyl ether

実験手順

5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.

出典