反応 #956412

反応方程式

sodium hydrogen carbonate

sodium sulfite

1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene

m-chloroperbenzoic acid

→

2-(isopropylsulfonyl)-4-methyl-1-nitrobenzene

溶媒

chloroform

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他After the reaction liquid
3. 3
   温度was cooled
4. 4
   その他the reaction liquid
5. 5
   抽出was extracted with chloroform
6. 6
   乾燥After the organic layer was dried over anhydrous sodium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

To a mixture of 1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene (Preparation Example 287) (6.60 g) and chloroform (150 mL), m-chloroperbenzoic acid (18.0 g) was added and stirred at 50° C. for 12 hours. After the reaction liquid was cooled, saturated aqueous sodium hydrogen carbonate and 5% aqueous sodium sulfite were added, and the reaction liquid was extracted with chloroform. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to give 2-(isopropylsulfonyl)-4-methyl-1-nitrobenzene (7.41 g) as a yellow solid.

出典