反応 #956411

反応方程式

propane-2-thiol

potassium carbonate

DMF

1-fluoro-4-methyl-2-nitrobenzene

→

1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他the reaction liquid
3. 3
   抽出was extracted with ethyl acetate
4. 4
   洗浄the extract was washed with water and saturated aqueous sodium chloride
5. 5
   乾燥After drying over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

To a mixture of propane-2-thiol (3.30 mL), potassium carbonate (6.60 g) and DMF (40 mL), 1-fluoro-4-methyl-2-nitrobenzene (4.85 g) was added and stirred at room temperature for 5 hours. After addition of water, the reaction liquid was extracted with ethyl acetate, and the extract was washed with water and saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to give 1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene (6.60 g) as a yellow oil.

出典