反応 #9560

反応方程式

(7-Bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine

→

7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine

溶媒

toluene

toluene

反応条件

後処理

1. 1
   その他The vessel was evacuated
2. 2
   workup.ADDITIONcharged with hydrogen (54 psi, 3.7×105 Pa)
3. 3
   その他The reaction mixture evacuated
4. 4
   ろ過filtered through a layer of CELITE
5. 5
   ろ過filter aid
6. 6
   濃縮concentrated under reduced pressure

実験手順

(7-Bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine (117 g) was dissolved in hot toluene (2 L) and poured into stainless steel Parr vessel. Additional toluene (2 L) and 5% platinum on carbon (12.5 g) were added. The vessel was evacuated, charged with hydrogen (54 psi, 3.7×105 Pa), and shaken overnight at room temperature. The reaction mixture evacuated, filtered through a layer of CELITE filter aid, and concentrated under reduced pressure to provide 7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine, which was used without purification.

出典