反応 #955955

反応方程式

acetic anhydride

butyl pyruvate

acetic anhydride

→

butyl α-acetoxyacrylate

収率 67.1%

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他to obtain a second reaction solution
3. 3
   その他was removed from the second reaction solution
4. 4
   workup.DISTILLATIONThereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.)

実験手順

Next, in a mixture of the obtained butyl pyruvate (235 g, 1.6 mol) and acetic anhydride (333 g, 3.3 mol), p-toluenesulfonic acid monohydrate (5 g) was added. Then, the mixture was stirred under a nitrogen gas stream at 120° C. for 25 hours to obtain a second reaction solution. Next, acetic acid generated by a reaction with excess acetic anhydride under reduced pressure (5 mmHg) was removed from the second reaction solution. Thereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.) to obtain butyl α-acetoxyacrylate (200 g, yield 67%).

出典