反応 #955954

反応方程式

pyruvic acid

n-butanol

→

butyl pyruvate

収率 70.1%

溶媒

toluene

反応条件

後処理

1. 1
   温度refluxed for 16 hours
2. 2
   その他while removing water under a nitrogen gas stream, whereby a first reaction solution
3. 3
   その他was obtained
4. 4
   その他Thereafter, toluene was removed under reduced pressure (40 mmHg)
5. 5
   その他an evaporator
6. 6
   workup.DISTILLATIONthe residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.)

実験手順

First, a toluene (1 L) solution of pyruvic acid (440 g, 5.0 mol), n-butanol (371 g, 5.0 mol) and p-toluenesulfonic acid monohydrate (2.5 g) was heated and refluxed for 16 hours while removing water under a nitrogen gas stream, whereby a first reaction solution was obtained. Next, the first reaction solution was cooled to room temperature (25° C.). Thereafter, toluene was removed under reduced pressure (40 mmHg) using an evaporator, and the residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.), whereby butyl pyruvate (505 g, yield 70%) was obtained.

出典