反応 #955938

反応方程式

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

収率 96.0%

溶媒

H2SO4

反応条件

後処理

1. 1
   温度was refluxed overnight
2. 2
   その他MeOH was evaporated
3. 3
   抽出the residue was extracted to EtOAc
4. 4
   洗浄successively washed with water and brine
5. 5
   乾燥dried over MgSO4
6. 6
   ろ過filtered
7. 7
   その他evaporated

実験手順

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

出典