反応 #95564

反応方程式

pelargonoyl chloride

N,N-bis(hydroxyethyl)hydroxyacetamide

→

N,N-bis(Pelargonoyloxyethyl)pelargonoylacetamide

溶媒

pyridine

反応条件

後処理

1. 1
   ろ過The precipitated pyridine hydrochloride was filtered
2. 2
   洗浄washed with benzene
3. 3
   洗浄washed
4. 4
   乾燥dried over sodium sulfate
5. 5
   その他to remove any acid
6. 6
   その他a rotary evaporator

実験手順

106 g (0.6 mole) of pelargonoyl chloride was added dropwise with stirring to a solution of 32.6 g (0.2 mole) of N,N-bis(hydroxyethyl)hydroxyacetamide in 60 ml of pyridine. The precipitated pyridine hydrochloride was filtered, washed with benzene, and discarded. The benzene solution of product was water washed, dried over sodium sulfate, and passed through an activated alumina column to remove any acid. The benzene was stripped off an a rotary evaporator. The yield of product was essentially quantitative. Its structure was established by infrared and nuclear magnetic resonance spectroscopy. It had nD30 1.4537 and d430 0.9745.

出典