反応 #95556

反応方程式

HCl

Sodium borohydride

cis 2-(1-hydroxy-2,2,2-trichloroethyl)-3,3-dimethylcyclopropane carboxylic acid

sodium borohydride

→

desired product

収率 25.0%

4-dichloromethyl-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one

収率 25.0%

溶媒

dimethylformamide

water

反応条件

後処理

1. 1
   温度the mixture was heated for a further 15 minutes at 80° C
2. 2
   抽出extracted with deuterochloroform, CDCl3
3. 3
   洗浄The extract was washed with water and analysed by NMR, which

実験手順

Sodium borohydride (0.12 mmol) was added to a solution of cis 2-(1-hydroxy-2,2,2-trichloroethyl)-3,3-dimethylcyclopropane carboxylic acid (0.12 mol) in dry dimethylformamide (0.4 ml), and the mixture was heated for 30 minutes at 80° C. An additional amount of 0.12 mmol sodium borohydride was then added and the mixture was heated for a further 15 minutes at 80° C. It was then diluted with water, acidified with concentrated HCl and extracted with deuterochloroform, CDCl3. The extract was washed with water and analysed by NMR, which showed a yield of 25% of the desired product, with 30% of unconverted starting material.

出典