反応 #955

反応方程式

4-hydroxyethyl piperidine

N-benzyloxycarbonyl-S-methyl isothiourea

→

title compound

収率 41.0%

1-Benzyloxycarbonylamidino-4-hydroxyethyl piperidine

収率 41.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was refluxed overnight
2. 2
   その他Evaporation and flash chromatography on silica gel with ethyl acetate

実験手順

A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

出典