反応 #9547

反応方程式

8-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

4-phenyl butene

→

1-(2-methylpropyl)-8-(4-phenylbut-1-enyl)-1H-imidazo[4,5-c]quinolin-4-amine

収率 51.7%

反応条件

後処理

1. 1
   温度The reaction was heated overnight
2. 2
   その他purification (eluting with 95:5 chloroform:methanol)

実験手順

8-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (3.0 g, 9.4 mmol) was treated with 4-phenyl butene (4.2 mL, 28.2 mmol) according to the method described in Part B of Example 425. The reaction was heated overnight. Following chromatographic purification (eluting with 95:5 chloroform:methanol), 1.8 g of 1-(2-methylpropyl)-8-(4-phenylbut-1-enyl)-1H-imidazo[4,5-c]quinolin-4-amine were obtained as an off-white solid.

出典