反応 #9544

反応方程式

1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

N-bromosuccinimide

→

8-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]-quinolin-4-amine

収率 22.6%

溶媒

chloroform

反応条件

後処理

1. 1
   温度The resulting dark red solution was heated
2. 2
   温度at reflux for 45 minutes
3. 3
   その他A precipitate formed
4. 4
   その他was isolated by filtration
5. 5
   洗浄was washed with water and diethyl ether

実験手順

A solution of 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (30.0 g, 125 mmol) in chloroform (620 mL) was heated to 50° C., and N-bromosuccinimide (28.8 g, 162 mmol) was added in five portions over a period of five minutes. The resulting dark red solution was heated at reflux for 45 minutes, allowed to cool to ambient temperature, and stirred for one hour. A precipitate formed, was isolated by filtration, and was washed with water and diethyl ether to provide 9.0 g of 8-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]-quinolin-4-amine as a solid.

出典