反応 #95438

反応方程式

sodium hydroxide

3,6-dichloropyridazine

meta-aminophenol

→

3-(6-chloro-3-pyridazinyloxy)benzeneamine

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   温度The stirred mixture was heated
2. 2
   温度refluxed (150°-155° C.) for two hours
3. 3
   温度cooled
4. 4
   ろ過filtered
5. 5
   その他The filter cake was recrystallized from aqueous methanol

実験手順

A concentrated aqueous solution of 44 g of sodium hydroxide was added to a stirred solution of 149 g of 3,6-dichloropyridazine and 114.5 g of meta-aminophenol in 500 ml of dimethyl sulfoxide, at room temperature. The stirred mixture was heated, refluxed (150°-155° C.) for two hours, cooled, and filtered. The filter cake was recrystallized from aqueous methanol to give 3-(6-chloro-3-pyridazinyloxy)benzeneamine (1A), as an off-white solid, mp: 76°-77° C.

出典